Overcoming the Challenges of Sample Preparation and LC/MS/MS Method
Development for Clinical Applications
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Many different biological matrices are processed in the clinical industry, each of which poses unique challenges for sample cleanup and analysis. In addition to complicated matrices, analytes are often analyzed at low levels, which plays a role in the selection of a sample preparation technique. The separation and selectivity provided by LC/MS/MS can help to overcome many of these challenges, however effective sample cleanup is still important.
This webinar will review method development and optimization with a special focus on sample preparation techniques, such as solid phase extraction (SPE), protein precipitation (PPT), and phospholipid removal.
Attendees will learn:
- How to determine the best sample preparation technique to achieve their analysis goals
- Method development tips for achieving separation of target compounds via LC/MS/MS
- How to increase throughput without sacrificing results