The Elyaman lab at Columbia University studies the recruitment and role of adaptive T cells in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Capitalizing on advancements in microfluidics chip-based cell sorting capabilities of the MA900 Multi-Application Cell Sorter and single cell sequencing technologies, this lab has delineated a first-in-human comprehensive view of the immunological landscape in the brain and its borders. The ultimate goal of these studies is to better understand how the brain-border immunity is altered in human neurodegeneration and its effects on CNS inflammation.
In line with previous mouse work, the lab has found that resident T cells in the choroid plexus likely play an immunoregulatory role that controls migration of immune cells across the blood/CSF barrier.
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